In this study, adult vaccination status and factors influencing vaccination behaviors among individuals aged 65 years and older were evaluated. It was observed that seasonal influenza and pneumococcal vaccines were administered at higher rates compared with other vaccines, whereas the herpes zoster vaccine remained at a very low level. The findings are generally consistent with both national and international literature and indicate that vaccination rates among the elderly population have still not reached the desired levels.
In a study conducted in Türkiye, vaccination rates for influenza, pneumococcal, and herpes zoster vaccines were reported as 21.8%, 4.3%, and 1.8%, respectively [7]. Similarly, a study conducted in 2010 reported that 51.5% of individuals aged over 65 years had received the influenza vaccine within the previous year, whereas only 16.5% had received the pneumococcal vaccine within the past five years [10]. In a larger sample study carried out between 2017 and 2018, the most frequently administered vaccine among 2,294 individuals aged over 65 years was influenza (33.7%), followed by adult-type diphtheria–tetanus (13.3%) and pneumococcal (7.9%) vaccines [11]. In another study conducted during a similar period, 33.94% of 303 individuals aged 65 years and older had received the influenza vaccine, 9.91% the pneumococcal vaccine, and 1.34% the tetanus vaccine; moreover, the vast majority of vaccinated individuals (94.42%) had preferred the influenza vaccine [12]. The pneumococcal vaccination rate of 46.7% observed in our study may be attributable to increased awareness generated by the pandemic.
Similarly, pneumococcal vaccination rates among individuals aged ≥65 years have been reported to range between 39% and 76% in Australia, while in the United States the pneumococcal vaccination rate among individuals aged 19–64 years in risk groups has been reported to be only 23% [13,14]. Our seasonal influenza vaccination rate of 33.2% is lower than the 46% reported in the United States but higher than rates reported in Türkiye. This finding suggests that, although progress has been made in vaccination practices in our country, vaccination coverage remains far from the desired targets.
The literature indicates that influenza and pneumococcal infections cause significant morbidity and mortality among older adults and that prevention is critically important in this population due to existing risk factors [5,8,9,15–17]. In our study, significantly higher seasonal influenza and pneumococcal vaccination rates among individuals with chronic disease, pulmonary disease, diabetes, or cardiovascular disease are consistent with these findings. Indeed, it has been reported that both influenza and pneumococcal vaccines reduce complications and hospitalizations among individuals with chronic obstructive pulmonary disease (COPD), and that vaccination rates are higher in the presence of chronic disease [5,15]. This relationship between comorbidities and vaccination underscores the decisive role of awareness and physician recommendations in high-risk groups [5,13,15,17].
In addition, influenza infection has been shown to have serious consequences not only for the respiratory system but also for the cardiovascular system. In the study by Smeeth et al., no increase in cardiovascular events was observed following seasonal influenza vaccination; however, the risk of acute cardiovascular events increased fivefold and the risk of stroke increased threefold within the first three days following a respiratory tract infection [6]. Similarly, the systematic review by Warren-Gash et al. provided strong evidence that influenza infection triggers acute myocardial infarction and cardiovascular mortality [7]. These findings suggest that influenza vaccination may indirectly reduce the risk of cardiovascular events, particularly among older individuals with cardiovascular comorbidities.
Accordingly, the association observed in our study between the presence of chronic disease and higher vaccination rates is consistent with clinical outcomes reported in the literature and supports the notion that vaccination in high-risk groups may reduce not only infectious complications but also cardiovascular events that contribute to mortality. Nevertheless, the persistently suboptimal vaccination rates in the general population remain noteworthy.
In our study, a significant association was found between educational level and vaccination status. Higher vaccination rates among individuals with a high school education or higher are consistent with literature demonstrating that education positively influences vaccination behaviors [9,14]. This may be explained by greater awareness of the protective effects of vaccines among individuals with higher educational attainment. In addition, the finding that Td vaccination rates were higher among individuals who had received influenza and pneumococcal vaccines suggests a clustering tendency in vaccination behaviors. The literature similarly reports that individuals who accept one vaccine are more likely to receive other adult vaccines, which is in line with our findings [9,18]. This result highlights the importance of a “vaccine bundling” approach in family medicine practice, in which multiple vaccines are recommended during the same visit.
The onset of the COVID-19 pandemic in Türkiye in March 2020 and the implementation of population-level interventions worldwide and nationally—such as social distancing, mask use, hygiene measures, school closures, and remote working—aimed at reducing SARS-CoV-2 transmission also markedly reduced the circulation of influenza and other respiratory viruses [19]. Indeed, compared with previous influenza seasons, the number of detected influenza and other respiratory viruses during the 2020/21 influenza season reached the lowest levels ever recorded both globally and in Türkiye [19]. Under these conditions, a reduction in perceived risk of influenza infection and a consequent decline in vaccination demand render low seasonal influenza vaccination rates an expected finding.
n a study conducted in Türkiye, vaccination rates for influenza, pneumococcal, and herpes zoster vaccines were reported as 21.8%, 4.3%, and 1.8%, respectively [7]. Similarly, a study conducted in 2010 reported that 51.5% of individuals aged over 65 years had received the influenza vaccine within the previous year, whereas only 16.5% had received the pneumococcal vaccine within the past five years [10]. In a larger sample study carried out between 2017 and 2018, the most frequently administered vaccine among 2,294 individuals aged over 65 years was influenza (33.7%), followed by adult-type diphtheria–tetanus (13.3%) and pneumococcal (7.9%) vaccines [11]. In another study conducted during a similar period, 33.94% of 303 individuals aged 65 years and older had received the influenza vaccine, 9.91% the pneumococcal vaccine, and 1.34% the tetanus vaccine; moreover, the vast majority of vaccinated individuals (94.42%) had preferred the influenza vaccine [12]. The pneumococcal vaccination rate of 46.7% observed in our study may be attributable to increased awareness generated by the pandemic.
Similarly, pneumococcal vaccination rates among individuals aged ≥65 years have been reported to range between 39% and 76% in Australia, while in the United States the pneumococcal vaccination rate among individuals aged 19–64 years in risk groups has been reported to be only 23% [13,14]. Our seasonal influenza vaccination rate of 33.2% is lower than the 46% reported in the United States but higher than rates reported in Türkiye. This finding suggests that, although progress has been made in vaccination practices in our country, vaccination coverage remains far from the desired targets.
The literature indicates that influenza and pneumococcal infections cause significant morbidity and mortality among older adults and that prevention is critically important in this population due to existing risk factors [5,8,9,15–17]. In our study, significantly higher seasonal influenza and pneumococcal vaccination rates among individuals with chronic disease, pulmonary disease, diabetes, or cardiovascular disease are consistent with these findings. Indeed, it has been reported that both influenza and pneumococcal vaccines reduce complications and hospitalizations among individuals with chronic obstructive pulmonary disease (COPD), and that vaccination rates are higher in the presence of chronic disease [5,15]. This relationship between comorbidities and vaccination underscores the decisive role of awareness and physician recommendations in high-risk groups [5,13,15,17].
In addition, influenza infection has been shown to have serious consequences not only for the respiratory system but also for the cardiovascular system. In the study by Smeeth et al., no increase in cardiovascular events was observed following seasonal influenza vaccination; however, the risk of acute cardiovascular events increased fivefold and the risk of stroke increased threefold within the first three days following a respiratory tract infection [6]. Similarly, the systematic review by Warren-Gash et al. provided strong evidence that influenza infection triggers acute myocardial infarction and cardiovascular mortality [7]. These findings suggest that influenza vaccination may indirectly reduce the risk of cardiovascular events, particularly among older individuals with cardiovascular comorbidities.
In our study, a significant association was found between educational level and vaccination status. Higher vaccination rates among individuals with a high school education or higher are consistent with literature demonstrating that education positively influences vaccination behaviors [9,14]. This may be explained by greater awareness of the protective effects of vaccines among individuals with higher educational attainment. In addition, the finding that Td vaccination rates were higher among individuals who had received influenza and pneumococcal vaccines suggests a clustering tendency in vaccination behaviors. The literature similarly reports that individuals who accept one vaccine are more likely to receive other adult vaccines, which is in line with our findings [9,18]. This result highlights the importance of a “vaccine bundling” approach in family medicine practice, in which multiple vaccines are recommended during the same visit.
The onset of the COVID-19 pandemic in Türkiye in March 2020 and the implementation of population-level interventions worldwide and nationally—such as social distancing, mask use, hygiene measures, school closures, and remote working—aimed at reducing SARS-CoV-2 transmission also markedly reduced the circulation of influenza and other respiratory viruses [19]. Indeed, compared with previous influenza seasons, the number of detected influenza and other respiratory viruses during the 2020/21 influenza season reached the lowest levels ever recorded both globally and in Türkiye [19]. Under these conditions, a reduction in perceived risk of influenza infection and a consequent decline in vaccination demand render low seasonal influenza vaccination rates an expected finding.
Our findings demonstrate that the COVID-19 pandemic created a pronounced “awareness effect” on adult immunization. The increase in pneumococcal vaccination rates to 31.7% after the pandemic—nearly doubling pre-pandemic levels—and the rise in influenza vaccination to 12.2% suggest strengthened motivation for protection against respiratory infections. Similarly, the literature reports an increase in the number of adults who received or planned to receive influenza and pneumococcal vaccines during the pandemic compared with previous seasons [20]. In a study conducted in Türkiye, 84.3% of individuals aged over 65 years stated that the pandemic had positively influenced their general attitudes toward vaccination, supporting this increase in awareness [21]. In a population-based study conducted in Taiwan, individuals with high levels of knowledge about COVID-19 were shown to have significantly increased tendencies to receive influenza and pneumococcal vaccines [22]. In our study, near-universal influenza and pneumococcal vaccination rates among individuals who perceived themselves as being in a risk group, were vaccinated due to chronic disease, or believed in the protective effects of vaccines further demonstrate that the pandemic was a powerful trigger for adult immunization. Taken together, these findings emphasize that the COVID-19 pandemic has acted as an important catalyst for increasing vaccine awareness in the adult population and that strengthening national adult immunization strategies is necessary to sustain this increase [8,23,24].
Indeed, a study conducted among hospitalized COVID-19 patients aged 65 years and older demonstrated that adult vaccination status was a determinant of disease severity and mortality. In that study, mortality among unvaccinated individuals was 2.2 times higher than among those who had received at least two vaccine doses, and mortality rates decreased progressively with increasing numbers of vaccine doses [25]. This finding supports the notion that the pandemic represents not only an opportunity to improve acceptance of COVID-19 vaccination but also a critical foundation for strengthening the uptake of other adult vaccines such as influenza and pneumococcal vaccines.
The extremely low herpes zoster vaccination rates observed in our study suggest deficiencies in awareness, access limitations, and reimbursement issues within adult immunization programs in our country. The literature similarly reports that cost and access barriers underlie the low uptake of the herpes zoster vaccine [13,26]. Our findings indicate that adult vaccines other than influenza and pneumococcal vaccines remain insufficiently utilized in Türkiye. Therefore, integrating the herpes zoster vaccine—alongside seasonal influenza and pneumonia vaccines—into routine immunization programs for older adults, particularly those with chronic diseases, is of critical importance for providing comprehensive protection and reducing the burden of infectious diseases.