Articleposted 2025-02-11 08:51:17
A clinical drug candidate that triggers non-apoptotic cancer cell death
Scott Dixon, Logan Leak, Ziwei Wang, Weaverly Colleen Lee, Brianna Johnson, Alec Millner, Pin-Joe Ko, and 15 more authors
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Articleposted 2025-01-29 06:31:52
Designing small molecules that target a cryptic RNA binding site via base displacement
Robert Batey, Lukasz Olenginski, Aleksandra Wierzba, Shawn Laursen
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Articleposted 2024-11-19 12:17:11
Navigating condensate microenvironment to enhance small molecule drug targeting
Tingting Li, Xin Zhang, Jian Ouyang, Junlin Chen, Zhili Wu, Kaiqiang You, Taoyu Chen, and 2 more authors
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Biological Sciences - Articleposted 2024-08-21 06:57:31
A widespread metabolic gene cluster family in metazoans
Bradley Moore, Natalie Grayson, Paul Scesa, Malia Moore, Jean-Baptiste Ledoux, Jessica Gomez-Garrido, Tyler Alioto, and 3 more authors
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Articleposted 2024-07-29 01:21:54
Accurate single domain scaffolding of three non-overlapping protein epitopes using deep learning
Bruno Correia, Karla Castro, Joseph Watson, Jue Wang, Joshua Southern, Reyhaneh Ayardulabi, Sandrine Georgeon, and 2 more authors
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Biological Sciences - Articleposted 2024-06-05 06:04:54
Cysteine allostery and autoinhibition govern human STING oligomer functionality
Lingyin Li, Rebecca Chan, Xujun Cao, Sabrina Ergun, Evert Njomen, Stephen Lynch, Christopher Ritchie, and 1 more authors
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Articleposted 2024-04-17 20:31:24
Far-red and sensitive sensor for monitoring real time H2O2 dynamics with subcellular resolution and in multi-parametric imaging applications.
Shani Zuniga, Patrick Boyle, Elizabeth Nance, David Mack, Jessica Young, Michael Regnier, Farid Moussavi-Harami, and 13 more authors
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Articleposted 2024-04-05 06:48:18
Engineering controllable alteration of malonyl-CoA levels to enhance polyketide production and versatility in E. coli
Jay Keasling, Sarah Klass, Mia Wesselkamper, Aidan Cowan, Namil Lee, Seokjung Cheong, Zilong Wang, and 3 more authors
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Articleposted 2024-03-13 03:09:21
Expanding Catalytic Versatility of Modular Polyketide Synthases for Alcohol Biosynthesis
Lihan Zhang, Shunyu Yao, Shengling Xie, Runzhou Liu, Zilei Huang
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Articleposted 2024-03-12 15:59:47
Plug-and-Play Engineering of Modular Polyketide Synthases
Lihan Zhang, Zilei Huang, Shengling Xie, Runzhou Liu, Changjun Xiang, Shunyu Yao
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