Research Articleposted 2025-12-03 11:36:38
The Human LRRK2-R1441G Mutation Drives Age-Dependent Oxidative Stress and Mitochondrial Dysfunction in Dopaminergic Neurons
Yuanxin Chen, Lianteng Zhi, Shiquan Cui, Huaixin Wang, Chenbo Zeng, Hui Zhang
Under Review
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Research Articleposted 2025-09-15 17:56:27
Developmental Dopamine Loss Rewires Striatal Circuits to Promote Locomotion
Jie Dong, Breanna T. Sullivan, Victor M. Martinez Smith, Lupeng Wang, Lulu Tian, Justin Kung, Bin Song, and 8 more authors
Published
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Research Articleposted 2025-07-18 14:30:51
M102 activates both NRF2 and HSF1 transcription factor pathways and is neuroprotective in cell and animal models of amyotrophic lateral sclerosis
Amy F. Keerie, Raquel Rua Martins, Chloe F. Allen, Sufana Al Mashhadi, Katie Bowden, Thomas Marlow, Monika Myszczynska, and 14 more authors
Published
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Research Articleposted 2025-07-18 14:10:20
Synaptic dysfunction and glial activation markers throughout aging and early neurodegeneration: a longitudinal CSF biomarker-based study
Mariana I. Muñoz-García, Yuetiva Deming, Ferran Lugo Hernández, Sterling Johnson, Sanjay Asthana, Gwendlyn Kollmorgen, Clara Quijano-Rubio, and 9 more authors
Published
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Research Articleposted 2025-06-29 15:01:08
High-sensitivity plasma proteomics reveals disease-specific signatures and predictive biomarkers of Alzheimer’s disease phenotypes in a large mixed dementia cohort
Katherine Gong, Jigyasha Timsina, Muhammad Ali, Yike Chen, Menghan Liu, Ciyang Wang, Cyril Pottier, and 12 more authors
Published
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Research Articleposted 2025-04-02 14:59:16
The UNC5C T835M mutation associated with Alzheimer’s disease leads to neurodegeneration involving oxidative stress and hippocampal atrophy in aged mice
Devi Krishna Priya Karunakaran, Makenna Ley, Joanna Guo, Ammaarah Khatri, Katherine Sadleir, Jelena Popovic, Arun Kumar Upadhyay, and 4 more authors
Published
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Research Articleposted 2025-02-24 06:01:17
Inhibition of Soluble Epoxide Hydrolase Confers Neuroprotection and Restores Microglial Homeostasis in a Tauopathy Mouse Model
Shuo Wang, Chuangye Qi, Chetan Rajpurohit, Baijayanti Ghosh, Wen Xiong, Baiping Wang, Yanyan Qi, and 5 more authors
Published
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Research Articleposted 2024-10-18 08:53:16
Repetitive transcranial magnetic stimulatation alleviates motor impairment in Parkinson's disease: association with peripheral inflammatory regulatory T-cells and SYT6
Zhaohua Zhu, Qing Wang, Eng-King Tan, Ling-Ling Chan, K Ray Chaudhuri, Lucia Batzu, Chengwu Yang, and 10 more authors
Published
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Research Articleposted 2024-09-12 13:23:33
Biophysical mapping of TREM2-ligand interactions reveals shared surfaces for engagement of multiple Alzheimer’s disease ligands
Jessica Greven, Joshua Wydra, Rory Greer, Cynthia Zhi, Christopher Camitta, Yuhua Song, Jennifer Alexander-Brett, and 1 more authors
Published
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Research Articleposted 2024-05-22 09:33:28
VCP regulates early tau seed amplification via specific cofactors
Sushobhna Batra, Jaime III Vaquer-Alicea, Clarissa Valdez, Skyler P Taylor, Victor A Manon, Anthony R Vega, Omar M Kashmer, and 5 more authors
Published
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