Research Articleposted 2025-12-22 09:12:47
SLC39-driven zinc influx orchestrates pleiotropic tumor–immune crosstalk to establish an immune-suppressive microenvironment in colorectal cancer
Seok June Hong, Seheum Park, Sunghoon Kim, Young Il Park, Mikyung Kang, Jaewoong Lee, Martin Hemberg, and 2 more authors
Under Review
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Research Articleposted 2025-10-20 13:40:03
Inhibition of PRMT5 triggers synthetic lethality in ARID1A-deficient endometrial cancer cells by promoting aberrant R-loop accumulation
Wan Shu, Kejun Dong, xiaoyu Shen, Xing Zhou, Jiarui Zhang, Shuyang Yu, Shuangshuang Cheng, and 5 more authors
Under Revision
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Research Articleposted 2025-10-15 17:13:54
Targeting circGDI2 disrupt HNRNPC-mediated mPORCN stabilization and enhance LGK-974 anti-tumor therapy in hepatocellular carcinoma
Yang Huang, Liangliang Xu, Linfeng Yang, Zhenru Wu, Li Li, Yu Dai, Junlong Dai, and 4 more authors
Under Revision
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Research Articleposted 2025-09-17 13:04:34
A Paracrine-to-Autocrine Shunt of GREM1 Fuels Colorectal Cancer Metastasis via ACVR1C
Huaixiang Zhou, Qunlong Jin, Zhang Fu, Yanming Yang, Yunfei Gao, Niu Wang, Bo Zhao, and 14 more authors
Under Review
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Research Articleposted 2025-09-12 14:27:11
Machine Learning Model on Multi-Omics Data Enables Risk Stratification and Identifies Molecular Heterogeneity and Therapeutic Targets in Glioblastoma
Zhenyu Zhang, Zilong Wang, Ran Li, Dongling Pei, Jingdian Liu, Yuning Qiu, Zaoqu Liu, and 28 more authors
Under Revision
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Research Articleposted 2025-07-14 10:11:39
A machine-learning powered liquid biopsy predicts response to Paclitaxel plus Ramucirumab in advanced gastric cancer: Results from the prospective IVY trial
Katsutoshi Shoda¹², Caiming Xu¹³, Takeshi Nagasaka⁴, Daisuke Ichikawa², Ajay Goel¹⁵
Published
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Research Articleposted 2025-05-07 06:24:52
Modeling CIC::DUX4 sarcoma reveals oncogene-mediated MHCI-dependent immune evasion
Ajay Vachanaram, Erdong Wei, Ana Mitanoska, William Bassett, Michael Kyba, Darko Bosnakovski
Published
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Research Articleposted 2025-04-10 10:13:59
Multi‑omics analysis identifies different molecular subtypes with unique outcomes in early-stage poorly differentiated lung adenocarcinoma
Yuge Zhu, Nan Wu, Shi Yan, Weizhi Chen, Yu S. Huang, Enli Zhang, Tongyang Gong, and 10 more authors
Published
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Research Articleposted 2025-01-15 17:06:30
Establishing 3D Organoid Models from Patient-Derived Conditionally Reprogrammed Cells to Bridge Preclinical and Clinical Insights in Pancreatic Cancer
Jin Su Kim, Chan Hee Park, Jinyoung Lee, Jeehoon Kim, Eun Hee Kam, Sanghee Nam, Hee Seung Lee, and 3 more authors
Published
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Research Articleposted 2024-12-09 13:09:51
Single cell and spatial analysis of immune-hot and immune-cold tumours identifies fibroblast subtypes associated with distinct immunological niches and positive immunotherapy response
Hailing Zong, Gareth J Thomas, Christopher J Hanley, Jamie G Bates, Emma V King, Lauri Diehl, Li Li, and 10 more authors
Published
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