Research Articleposted 2025-12-15 17:43:17
Biomarker-Driven Computational PK/PD Modeling and Dosing Optimization of the Targeted Protein Degrader Fulvestrant in Estrogen Receptor–Positive Breast Cancer
Nikhil Srinivasan
Under Review
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Research Articleposted 2025-07-08 06:21:27
Exposure-Safety Analyses of Talazoparib in Combination with Enzalutamide in Patients with Metastatic Castration-Resistant Prostate Cancer (mCRPC) in the TALAPRO-2 Trial
Yibo Wang, Mark Hadigol, Victor Ruberio Lincha, Justin Hoffman, Arun A. Azad, Neeraj Agarwal, Nobuaki Matsubara, and 3 more authors
Under Review
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Research Articleposted 2025-05-07 08:45:50
A QSP PDE Model of Adc Transport and Kinetics in Agrowing or Shrinking Tumor
David Ross, Antonio Cabal
Published
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Research Articleposted 2025-04-28 10:13:45
Leveraging Large Language Models in Pharmacometrics: Evaluation of NONMEM Output Interpretation and Simulation Capabilities
Hwa Jun Cha, Kyuyeon Choe, Euibeom Shin, Murali Ramanathan, Sungpil Han
Published
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Research Articleposted 2025-01-22 09:22:17
An automated pipeline to generate initial estimates for population pharmacokinetic models
Zhonghui Huang, Matthew Fidler, Minshi Lan, lek L Cheng, Frank Kloprogge, Joseph F Standing
Published
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Research Articleposted 2024-11-08 10:50:50
Quantifying natural amyloid plaque accumulation in the continuum of Alzheimer’s disease using ADNI
Marwa E. Elhefnawy, Noel Patson, Samer Mouksassi, Goonaseelan (Colin) Pillai, Sergey Shcherbinin, Emmanuel Chigutsa, Ivelina Gueorguieva
Published
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Research Articleposted 2024-08-28 20:00:24
Model informed approach to estimate treatment effect in placebo- controlled clinical trials using an artificial intelligence based propensity weighting methodology to account for non-specific responses to treatment
Roberto Gomeni, Francoise Bressolle-Gomeni
Published
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Research Articleposted 2024-08-14 07:57:48
Reliability of in vitro data for the mechanistic prediction of brain extracellular fluid pharmacokinetics of P-glycoprotein substrates in vivo; are we scaling correctly?
Daan Willem van Valkengoed, Makoto Hirasawa, Vivi Rottschäfer, Elizabeth Cunera Maria de Lange
Published
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Research Articleposted 2024-08-06 11:27:02
Whole-Body Physiologically-Based Pharmacokinetic Modeling of GalNAc conjugated siRNAs
Emilie Kirstine Langeskov Salim, Erik Sjögren, Kim Kristensen
Under Review
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Research Articleposted 2024-07-18 20:14:17
Application of Model-informed Drug Development (MIDD) in Regulatory Submissions for Drug Approval in Japan
Tomohiro Sasaki, Takayuki Katsube, Seiichi Hayato, Shingo Yamaguchi, Jun Tanaka, Hiroki Yoshimatsu, Yushi Nakanishi, and 5 more authors
Published
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